People who use or inject drugs should be vaccinated against hepatitis A, and people who inject drugs should be vaccinated against hepatitis B. People who inject drugs should be tested for hepatitis B and hepatitis C.

CDC and the Advisory Committee on Immunization Practices (ACIP) recommend that people who use drugs (PWUD) and people who inject drugs (PWID) get vaccinated against hepatitis A and that PWID get vaccinated against hepatitis B. Because of higher rates of infection among this population, CDC also recommends testing anyone who has injected drugs for hepatitis B. CDC now recommends one-time hepatitis C testing of all adults (people 18 years and older). CDC continues to recommend that people with risk factors, including people who inject drugs, be tested regularly.