If you had the Arizona Cardinals as the last unbeaten team in the NFL as of Week 5, please come and collect your winnings. Kliff Kingsbury’s team made a statement with their 37-20 thrashing of the Rams in Los Angeles. By outplaying Matthew Stafford, Kyler Murray firmly established himself as a leading MVP candidate, and all of the Cardinals’ offensive weapons were fully on display. Life at the top will stay stressful for Arizona, though; its next two opponents are the 49ers and Browns. There were other surprises in Week 4; Tampa Bay’s tilt with New England was more slop fest than classic, but Tom Brady ended a game in Gillette Stadium a winner yet again; the Giants and Jets both got their first wins of the season, and both needed overtime to do it; the Chargers knocked the Raiders from the ranks of the unbeaten, and the Bengals – yes, the Bengals – improved to 3-1 on the year. And Urban Meyer? Let’s just say things aren’t going great. Week 5 features several more marquee matchups, so let’s get to the games.

Point spreads are from DraftKings.com, and are current as of 11 a.m. ET Thursday.

NOTE: Pick with spread is in bold.

Last week: 9-7 (Season: 32-32)